ACS New Haven, CtLocal Section

April New Haven Dinner Meeting

 

Join us for our April General Meeting,

 

Ms. Nicole Langlois

New Haven ACS Undergraduate Student Research Awardee

University of New Haven

(mentor Professor Pier Cirello)

 

Progress toward the Synthesis of Cadiolides and Analogs

 

When: April, 11th 2018 

 

  Place: Brazi's Italian Restaurant

   201 Food Terminal Plaza, New Haven, CT 06511

 

   Please RSVP at click here

 Networking: 6:00 - 6:45 pm             

Buffet Dinner: 6:45 - 7:45 pm         

 Presentation: 7:45 - 9:00 pm

            Cost:    $10 for students & high school,

                        $15 for retired ACS members & spouses,

                        $20 for members and $25 for non members

Abstract

Cadiolides are a class of marine natural products that have been found to possess antibacterial potency against the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) at minimum inhibitory concentrations similar to, or lower than current leading antibiotics. In order for studies on the mechanism by which these structures act to kill or inhibit bacterial growth  to be conducted, a cost-effective and efficient synthesis must be accomplished and scaled up to yield multi-gram quantities of the cadiolides.

Our progress toward an efficient, simple synthesis of the cadiolides and analogous structures will allow for further studies to reveal their potential as antibiotics. The method followed involves the utilization of an acylated Meldrum’s acid adduct to form the initial step toward the key intermediate structures allowing for the use of cost-effective reagents. This unique synthesis, in that it allows for two major points of divergence, allows for the creation of a variety of analogs and follows a six-step process toward the production of Cadiolide B – a basic form among the most potent of the cadiolides.

 

 

May Meeting TBD